Self-immolative linkers in polymeric delivery systems
نویسندگان
چکیده
منابع مشابه
Self-immolative polymers.
The investigation of synthetic polymers for biological applications is increasing as assembly techniques for generating welldefined macromolecules from artificial building blocks become more sophisticated. Synthesis techniques have now evolved such that a wide variety of functional groups can be tolerated by polymerization catalysts, and a fascinating and diverse range of macromolecular and pol...
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Nowadays, design and synthesis of efficient drug delivery systems are of vital importance in order to optimize the efficacy of therapeutics and reducing side effects. So far, many drug delivery systems have been designed, among them, natural polymer-based systems have attracted the most attention. Silk fibroin (SF) as a natural polymer have several unique properties including excellent biocompa...
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We report that aryl phthalate esters are robust self-immolative linkers. This linker is easy to conjugate and releases output phenols upon cleaving a fluoride-sensitive mask to yield a benign phthalic acid byproduct, making these linkers potentially useful as fluoride sensors and promising for use in biological and materials applications.
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The purpose of drug delivery systems in cancer chemotherapy is to achieve selective delivery of anti-cancer agents to cancer tissue at an effective concentrations for the appropriate duration of time, so that we may be able to reduce the adverse effects of a drug and simultaneously enhance the anti-tumor effect. Polymeric micelles were expected to increase the accumulation of drugs in tumor tis...
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Polycations are explored as carriers to deliver therapeutic nucleic acids. Polycations are conventionally pharmacological inert with the sole function of delivering therapeutic cargo. This study reports synthesis of a self-immolative polycation (DSS-BEN) based on a polyamine analogue drug N(1),N(11)-bisethylnorspermine (BENSpm). The polycation was designed to function dually as a gene delivery ...
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ژورنال
عنوان ژورنال: Polym. Chem.
سال: 2011
ISSN: 1759-9954,1759-9962
DOI: 10.1039/c0py00324g